Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587329 | 0.78 | AGER (0.45) | GPR119HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL6587980 | 0.75 | HTR2C (0.38) | GPR119HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL6589364 | 0.74 | MEN1 (0.43) | GPR119SIRT2SIRT1JAK2JAK1 | |
| SCHEMBL2401141 | 0.71 | MEN1 (0.46) | HDAC1HDAC3HDAC2NCOR2HSD11B1 | |
| SCHEMBL2546335 | 0.71 | JAK2 (0.40) | GPR119HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL2546336 | 0.71 | JAK2 (0.40) | GPR119HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL2547511 | 0.71 | HDAC3 (0.37) | HDAC1HDAC3HDAC2NCOR2NR1H4 | |
| SCHEMBL6593681 | 0.71 | EPHX1 (0.40) | GPR119HDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL2547508 | 0.71 | HDAC3 (0.37) | HDAC1HDAC3HDAC2NCOR2NR1H4 | |
| SCHEMBL3117999 | 0.71 | AGER (0.48) | GPR119HDAC1HDAC3HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169338-B1 | LOW-MOLECULAR INHIBITORS OF COMPLEMENT PROTEASES | ABBOTT GMBH & CO KG (DE) | 2004-11-03 | — | — | EP | disclosed |
| US-6683055-B1 | GUANIDINE OR AMIDINE TERMINED PEPTIDES | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |