Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111617 | 0.89 | CHRM2 (0.32) | CHRM2CHRM1CHRM3CHRM4CTSL | |
| SCHEMBL6588417 | 0.89 | CHRM2 (0.32) | CHRM2CHRM1CHRM3CHRM4CTSL | |
| SCHEMBL6592697 | 0.86 | CTSL (0.33) | CTSLCTSSCTSKALDH1A1 | |
| SCHEMBL6590885 | 0.85 | CTSL (0.34) | CTSLCTSSCTSK | |
| SCHEMBL6591206 | 0.85 | SSTR4 (0.32) | CTSLCTSSCTSK | |
| SCHEMBL6586151 | 0.84 | ALDH1A1 (0.31) | CTSLCTSSCTSKALDH1A1 | |
| SCHEMBL7042962 | 0.82 | SSTR4 (0.31) | — | |
| SCHEMBL6590362 | 0.82 | SSTR4 (0.31) | — | |
| SCHEMBL6589594 | 0.82 | CTSL (0.33) | CTSLCTSSCTSK | |
| SCHEMBL6589057 | 0.81 | CTSL (0.31) | CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1413580-A1 | Furanone derivatives as inhibitors of Cathepsin S | Medivir UK Ltd (GB) | 2004-04-28 | — | — | EP | claimed |
| EP-1178986-B1 | FURANONE DERIVATIVES AS INHIBITORS OF CATHEPSIN S | MEDIVIR UK LTD (GB) | 2004-02-25 | — | — | EP | claimed |
| EP-1413580-A1 | Furanone derivatives as inhibitors of Cathepsin S | Medivir UK Ltd (GB) | 2004-04-28 | — | — | EP | disclosed |