Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.51 |
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587721 | 0.96 | SIGMAR1 (0.51) | SIGMAR1PARP1HTR1ADRD2DRD4 | |
| SCHEMBL6592540 | 0.90 | SIGMAR1 (0.58) | SIGMAR1PARP1HTR1ADRD2DRD4 | |
| Ssr-150106 SCHEMBL1385047 | 0.87 | SIGMAR1 (0.48) | SIGMAR1PARP1DRD2DRD4DRD3 | |
| Ssr-150106 SCHEMBL29393331 | 0.87 | SIGMAR1 (0.48) | SIGMAR1PARP1DRD2DRD4DRD3 | |
| SCHEMBL6590514 | 0.83 | SIGMAR1 (0.48) | SIGMAR1PARP1DRD2DRD4DRD3 | |
| SCHEMBL6587088 | 0.83 | SIGMAR1 (0.52) | SIGMAR1PARP1DRD2DRD4DRD3 | |
| SCHEMBL14277663 | 0.82 | PARP1 (0.48) | SIGMAR1PARP1HTR1ASLC6A3HTR7 | |
| SCHEMBL6608875 | 0.82 | PARP1 (0.50) | SIGMAR1PARP1HTR1ADRD2DRD4 | |
| SCHEMBL6594692 | 0.82 | PARP1 (0.50) | SIGMAR1PARP1HTR1ADRD2DRD4 | |
| SCHEMBL14277638 | 0.82 | PARP1 (0.47) | SIGMAR1PARP1HTR1ASLC6A3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |
| CN-1158276-C | Phenyl-and pyridyl-tetrahydropyridines with TNF inhibiting activity | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-07-21 | — | — | CN | disclosed |
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |