Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608875 | 0.92 | PARP1 (0.50) | PARP1SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL6598869 | 0.87 | PPARG (0.47) | PARP1KCNH2HRH3SIGMAR1DRD2 | |
| SCHEMBL6587721 | 0.82 | SIGMAR1 (0.51) | PARP1KCNH2SIGMAR1DRD2DRD4 | |
| SCHEMBL6589537 | 0.82 | SIGMAR1 (0.51) | PARP1SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL1138592 | 0.81 | SIGMAR1 (0.49) | PARP1SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL14277663 | 0.81 | PARP1 (0.48) | PARP1KCNH2HRH3SIGMAR1HTR1A | |
| SCHEMBL6597710 | 0.80 | PPARG (0.47) | PARP1KCNH2SIGMAR1DRD2DRD4 | |
| SCHEMBL14277638 | 0.80 | PARP1 (0.47) | PARP1KCNH2HRH3SIGMAR1HTR1A | |
| SCHEMBL14277641 | 0.79 | PARP1 (0.48) | PARP1SIGMAR1DRD2HTR1A | |
| SCHEMBL14277640 | 0.78 | PARP1 (0.47) | PARP1SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226137-B8 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI AVENTIS (FR) | 2004-12-15 | — | — | EP | disclosed |
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |
| CN-1158276-C | Phenyl-and pyridyl-tetrahydropyridines with TNF inhibiting activity | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-07-21 | — | — | CN | disclosed |
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |
| EP-1226137-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001029026-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2001-04-26 | — | — | WO | disclosed |