Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 16/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 16/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 16/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 15/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 15/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585505 | 0.86 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6587447 | 0.86 | CHRNB2 (0.56) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6583951 | 0.84 | CHRNB1 (0.61) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL6583208 | 0.82 | CHRNB1 (0.61) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7465912 | 0.82 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL7923228 | 0.81 | CHRNB1 (0.46) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL14216678 | 0.81 | TLR7 (0.36) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL14779759 | 0.81 | CYP11B1 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL14779765 | 0.81 | CYP11B1 (0.55) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL3357256 | 0.81 | CHRNB2 (0.44) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| US-5629325-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1997-05-13 | — | — | US | disclosed |