Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 5/20 | 0.50 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589784 | 0.95 | HTR1A (0.57) | DRD2DRD3DRD4HTR7HTR1A | |
| SCHEMBL6591109 | 0.94 | HTR1A (0.54) | DRD2DRD3DRD4HTR7HTR1A | |
| SCHEMBL6592086 | 0.91 | KCNH2 (0.53) | DRD2DRD3DRD4HTR7HTR1A | |
| SCHEMBL6582940 | 0.89 | KCNH2 (0.57) | DRD2HTR7HTR1AKCNH2SLC6A4 | |
| SCHEMBL6589532 | 0.86 | HTR1A (0.59) | DRD2HTR7HTR1AKCNH2SLC6A4 | |
| SCHEMBL6593294 | 0.86 | HTR1A (0.71) | DRD2DRD3DRD4HTR7HTR1A | |
| SCHEMBL7082110 | 0.86 | KCNH2 (0.54) | DRD2HTR7HTR1AKCNH2SLC6A4 | |
| SCHEMBL6592114 | 0.83 | HTR1A (0.67) | DRD2HTR7HTR1AKCNH2SLC6A4 | |
| SCHEMBL6592113 | 0.81 | DRD2 (0.59) | DRD2DRD3DRD4HTR7HTR1A | |
| SCHEMBL6591451 | 0.81 | HTR1A (0.66) | DRD2DRD3DRD4HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246816-B1 | SUBSTITUTED PHENYL-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2004-03-17 | — | — | EP | disclosed |
| EP-1246816-A1 | SUBSTITUTED PHENYL-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND USE | H. Lundbeck A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049678-A1 | SUBSTITUTED PHENYL-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |