Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 16/20 | 0.42 |
| ▸ | CTSL | P07711 | 12/20 | 0.42 |
| ▸ | CTSS | P25774 | 9/20 | 0.42 |
| ▸ | CTSB | P07858 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426386 | 0.92 | RAB9A (0.45) | CTSKCTSLCTSSCTSBRAB9A | |
| SCHEMBL5971256 | 0.85 | CTSK (0.55) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6593286 | 0.85 | CTSK (0.48) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6673927 | 0.84 | CTSK (0.39) | CTSKCTSLCTSSCTSBRAB9A | |
| SCHEMBL6206715 | 0.84 | CTSK (0.51) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4821292 | 0.83 | CTSK (0.56) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7009811 | 0.83 | CTSK (0.46) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6594151 | 0.81 | CTSK (0.47) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6592546 | 0.80 | PSEN1 (0.35) | RAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL6587856 | 0.77 | PSEN1 (0.35) | RAB9ANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307204-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1307204-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001095911-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |