Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589971 | 0.88 | CLK1 (0.46) | CLK1CLK2TSHRMAPK1MEN1 | |
| SCHEMBL6592058 | 0.79 | HIF1A (0.50) | CLK1CLK2TSHRMAPK1HCRTR1 | |
| SCHEMBL6596424 | 0.78 | CLK1 (0.46) | CLK1CLK2TSHRMAPK1HCRTR1 | |
| SCHEMBL6595994 | 0.71 | CLK1 (0.46) | CLK1CLK2HCRTR1HCRTR2PIN1 | |
| SCHEMBL6592930 | 0.70 | MTNR1A (0.53) | CLK1CLK2HCRTR1HCRTR2MAPT | |
| SCHEMBL6591345 | 0.67 | CLK1 (0.46) | CLK1CLK2TSHRMEN1MAPT | |
| SCHEMBL6594263 | 0.67 | CA1 (0.48) | CLK1CLK2TSHRHIF1AMAPT | |
| SCHEMBL5277894 | 0.67 | HPGD (0.58) | HCRTR1HCRTR2PIN1MEN1MAPT | |
| SCHEMBL3287656 | 0.66 | MAPT (0.46) | CLK1CLK2MAPT | |
| SCHEMBL3287653 | 0.66 | MAPT (0.46) | CLK1CLK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842927-B1 | 3-Amido-chromanylsulfonyl(thio)ureas, process for their preparation, their use and medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-02-25 | — | — | EP | disclosed |
| US-5849755-A | 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| EP-0842927-A1 | 3-Amido-chromanylsulfonyl(thio)ureas, process for their preparation, their use and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-20 | — | — | EP | disclosed |