Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591145 | 0.94 | PARP1 (0.46) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6583962 | 0.92 | PIM1 (0.53) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6591730 | 0.85 | AURKB (0.44) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6806654 | 0.85 | PARP1 (0.66) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6588091 | 0.84 | AURKB (0.51) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6587284 | 0.84 | AURKB (0.47) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL7538951 | 0.83 | PARP1 (0.47) | PARP1PIM1PIM3AURKBCLK4 | |
| SCHEMBL6588412 | 0.83 | AURKB (0.46) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6586278 | 0.83 | PARP1 (0.46) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6378302 | 0.83 | PARP1 (0.56) | PARP1MAP4K4PIM1PIM3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |