Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.50 |
| ▸ | PPARA | Q07869 | 5/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592542 | 0.89 | PPARG (0.49) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| SCHEMBL6589155 | 0.88 | PPARG (0.50) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| SCHEMBL5149448 | 0.86 | PPARG (0.47) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| SCHEMBL6588999 | 0.85 | PPARG (0.48) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| Xaliproden SCHEMBL137094 | 0.85 | SIGMAR1 (0.51) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| Xaliproden SCHEMBL29377982 | 0.85 | SIGMAR1 (0.51) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| SCHEMBL9366593 | 0.84 | PPARG (0.51) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| Xaliproden SCHEMBL116721 | 0.84 | SIGMAR1 (0.50) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| Xaliproden SCHEMBL29393004 | 0.84 | SIGMAR1 (0.50) | PPARGPPARAHTR7SIGMAR1PARP1 | |
| SCHEMBL6590514 | 0.84 | SIGMAR1 (0.48) | PPARGPPARAHTR7SIGMAR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |