Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592542 | 0.89 | PPARG (0.49) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| SCHEMBL9366389 | 0.88 | PPARG (0.53) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| SCHEMBL6591102 | 0.88 | PPARG (0.50) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| SCHEMBL4588155 | 0.87 | PPARG (0.51) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8742253 | 0.87 | PPARG (0.53) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8742634 | 0.86 | PPARG (0.50) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| SCHEMBL5149448 | 0.86 | PPARG (0.47) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| Xaliproden SCHEMBL137094 | 0.85 | SIGMAR1 (0.51) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| Xaliproden SCHEMBL29377982 | 0.85 | SIGMAR1 (0.51) | PPARGPPARAHTR7PARP1SIGMAR1 | |
| SCHEMBL9366593 | 0.84 | PPARG (0.51) | PPARGPPARAHTR7PARP1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |