Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 9/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591698 | 1.00 | CXCR4 (0.41) | CXCR4KDM1AMEN1CHRM2CHRM1 | |
| SCHEMBL6591700 | 0.79 | KDM1A (0.32) | KDM1A | |
| SCHEMBL7625662 | 0.76 | LMNA (0.38) | KDM1AMEN1CHRM2CHRM1KMT2A | |
| SCHEMBL7623454 | 0.75 | KMT2A (0.38) | KDM1AMEN1CHRM2CHRM1KMT2A | |
| SCHEMBL6604716 | 0.75 | CXCR4 (0.34) | CXCR4KDM1AMEN1CHRM2CHRM1 | |
| SCHEMBL22967499 | 0.74 | KDM1A (0.37) | CXCR4KDM1APOLBSMN1; SMN2SLC6A2 | |
| SCHEMBL9690498 | 0.72 | RAD52 (0.38) | CXCR4POLBSMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL17066768 | 0.71 | SLC6A2 (0.35) | MEN1KMT2AHRH3SLC6A2SLC6A4 | |
| SCHEMBL7433696 | 0.71 | SLC6A2 (0.35) | MEN1KMT2AHRH3POLBSLC6A2 | |
| SCHEMBL946201 | 0.71 | CXCR4 (0.62) | CXCR4KDM1AMEN1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069124-B1 | 2-Benzimidazolylamine compounds as ORL1-receptor agonists | PFIZER (US) | 2004-05-12 | — | — | EP | disclosed |