Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806440 | 0.90 | PARP1 (0.52) | PARP1PKN1PKN2ALOX15PLA2G2A | |
| SCHEMBL6806447 | 0.79 | ALDH1A1 (0.38) | PARP1PKN1PKN2ALDH1A1ALOX15 | |
| SCHEMBL6585822 | 0.75 | PARP1 (0.40) | PARP1PKN1PKN2ALOX15HPSE | |
| SCHEMBL6587758 | 0.70 | PARP1 (0.57) | PARP1PKN1PKN2ALDH1A1ALOX15 | |
| SCHEMBL6592104 | 0.67 | PIM1 (0.44) | PARP1PKN2ALDH1A1ALOX15HPGD | |
| SCHEMBL7480214 | 0.67 | HPSE (0.38) | PARP1PKN1PKN2ALDH1A1ALOX15 | |
| SCHEMBL12517226 | 0.66 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPTRAB9AGFER | |
| SCHEMBL6585381 | 0.66 | CBFB (0.67) | PARP1ALDH1A1ALOX15TP53CYP3A4 | |
| SCHEMBL6590709 | 0.66 | PKN1 (0.66) | PARP1PKN1PKN2ALOX15HPSE | |
| SCHEMBL6586509 | 0.64 | METAP1 (0.53) | PARP1PKN1PKN2ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |