Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.57 |
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CBFB | Q13951 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587920 | 0.86 | PARP1 (0.46) | PARP1PDE5AHPSEPKN1PKN2 | |
| SCHEMBL6806133 | 0.85 | PARP1 (0.75) | PARP1ALOX15PKN1PKN2DYRK1A | |
| SCHEMBL6585966 | 0.84 | PKN2 (0.48) | PARP1PDE5AALDH1A1SMN1; SMN2PKN1 | |
| SCHEMBL6588724 | 0.83 | PDE5A (0.51) | PARP1PDE5ACYP3A4PKN1PKN2 | |
| SCHEMBL6585579 | 0.83 | PKN2 (0.43) | PARP1PDE5APKN1PKN2DYRK1A | |
| SCHEMBL6586038 | 0.82 | PIM1 (0.51) | PARP1PDE5AALDH1A1CBFBPKN1 | |
| SCHEMBL6586074 | 0.82 | PIM1 (0.46) | PARP1PDE5ACBFBPKN1PKN2 | |
| SCHEMBL6583719 | 0.80 | PARP1 (0.43) | PARP1ALDH1A1AURKADYRK1APRKD3 | |
| SCHEMBL6586196 | 0.80 | BRD4 (0.44) | PARP1PRKCZPARP2 | |
| SCHEMBL6590709 | 0.80 | PKN1 (0.66) | PARP1HPSEALOX15PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |