SCHEMBL6592161

SCHEMBL6592161

O=C(O)c1nc2c(OCc3ccccc3)cccc2c(OCc2ccccc2)c1Br

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 1/20 0.46
FOLH1 Q04609 2/20 0.43
ADORA1 P30542 2/20 0.43
ADORA3 P0DMS8 1/20 0.43
ADORA2A P29274 1/20 0.43
HDAC6 Q9UBN7 2/20 0.43
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
SRD5A2 P31213 1/20 0.43
KDM4E B2RXH2 3/20 0.42
ALDH1A1 P00352 3/20 0.42
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6079596 0.90 MRGPRX4 (0.41) MRGPRX4FOLH1ADORA1ADORA3ADORA2A
SCHEMBL6079972 0.88 MRGPRX4 (0.46) MRGPRX4FOLH1ADORA1ADORA3ADORA2A
SCHEMBL6591062 0.85 MRGPRX4 (0.46) MRGPRX4FOLH1ADORA1ADORA3ADORA2A
SCHEMBL6594157 0.84 XDH (0.40) MRGPRX4KDM4EALDH1A1
SCHEMBL6079599 0.79 PTGER1 (0.42) FOLH1KDM4EALDH1A1CYP1A2PTGER1
SCHEMBL6607056 0.79 MRGPRX4 (0.42) MRGPRX4FOLH1ADORA1ADORA3ADORA2A
SCHEMBL6080351 0.78 MAPT (0.49) MRGPRX4FOLH1ADORA1ADORA3ADORA2A
SCHEMBL6080005 0.77 MAPT (0.48) MRGPRX4FOLH1ADORA1ADORA3ADORA2A
SCHEMBL6079907 0.77 PTGER1 (0.43) KDM4EALDH1A1MEN1KMT2APTGER1
SCHEMBL6080519 0.77 HPGD (0.43) MRGPRX4ADORA1ADORA3ADORA2AHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1451159-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2004-09-01 EP claimed
WO-2003010146-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2003-02-06 WO claimed
EP-1451159-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2004-09-01 EP disclosed
WO-2003010146-A1 COMPOSITIONS DERIVED FROM QUINOLINE AND QUINOXALINE, PREPARATION AND USE THEREOF NEURO3D (FR) 2003-02-06 WO disclosed