Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590142 | 0.88 | MAPT (0.51) | MAPTALDH1A1KDM4EMAOBCDK2 | |
| SCHEMBL6590310 | 0.85 | KMT2A (0.45) | MAPTALDH1A1KDM4ECDK2KMT2A | |
| SCHEMBL22450703 | 0.81 | KCNH2 (0.49) | MAPTALDH1A1KDM4EMAOBCDK2 | |
| SCHEMBL10258241 | 0.81 | KMT2A (0.52) | MAPTALDH1A1KDM4ECDK2KMT2A | |
| SCHEMBL7525730 | 0.79 | KMT2A (0.44) | MAPTALDH1A1KDM4EMAOBCDK2 | |
| SCHEMBL7502009 | 0.79 | KMT2A (0.41) | MAPTALDH1A1KDM4EMAOBCDK2 | |
| SCHEMBL6586386 | 0.78 | NR4A2 (0.64) | MAPTALDH1A1KMT2ALMNAMITF | |
| SCHEMBL25742017 | 0.78 | KMT2A (0.39) | MAPTALDH1A1KDM4EMAOBCDK2 | |
| SCHEMBL1019344 | 0.78 | P2RX7 (0.55) | KMT2AMEN1CACNA1H | |
| SCHEMBL10341160 | 0.77 | MAOB (0.56) | MAPTALDH1A1KDM4EMAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |