Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | RAB9A | P51151 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6593013 | 1.00 | MAPT (0.36) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3554226 | 0.82 | HTT (0.40) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3554224 | 0.82 | HTT (0.40) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6593940 | 0.82 | MAPT (0.37) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6593945 | 0.82 | MAPT (0.37) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6106911 | 0.79 | MAPK1 (0.38) | ALDH1A1SMN1; SMN2POLBLMNAGAA | |
| SCHEMBL6590360 | 0.78 | ALDH1A1 (0.37) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6590358 | 0.78 | ALDH1A1 (0.37) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5098850 | 0.78 | HTT (0.42) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5098848 | 0.78 | HTT (0.42) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |