Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.36 |
| ▸ | TACR2 | P21452 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596451 | 0.93 | ALDH1A1 (0.36) | LMNAMAPTALDH1A1TACR1 | |
| SCHEMBL6596461 | 0.92 | CHRM1 (0.39) | LMNAMAPTALDH1A1HRH1CHRM1 | |
| SCHEMBL6596700 | 0.92 | MEN1 (0.36) | LMNAMAPTALDH1A1TACR1TACR2 | |
| SCHEMBL6594416 | 0.92 | LMNA (0.35) | LMNAMAPTALDH1A1TACR1TACR2 | |
| SCHEMBL6594420 | 0.92 | LMNA (0.35) | LMNAMAPTALDH1A1TACR1TACR2 | |
| SCHEMBL6597910 | 0.90 | MAPT (0.35) | LMNAMAPTALDH1A1TACR1TACR2 | |
| SCHEMBL6595000 | 0.90 | HRH1 (0.37) | TACR1TACR2HRH1CYP2D6CHRM1 | |
| SCHEMBL6596468 | 0.87 | TACR2 (0.34) | LMNAMAPTALDH1A1TACR2DRD2 | |
| SCHEMBL6593743 | 0.87 | TACR2 (0.40) | LMNAMAPTALDH1A1TACR1TACR2 | |
| SCHEMBL6596980 | 0.87 | TACR2 (0.33) | TACR2DRD2DRD4HRH1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888338-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2004-11-17 | — | — | EP | disclosed |