Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | PMM2 | O15305 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695407 | 0.74 | TRIM58 (0.41) | ALDH1A1 | |
| SCHEMBL317826 | 0.73 | GPR3 (0.42) | GPR3EPAS1RAB9AG6PDKDM4E | |
| SCHEMBL66254 | 0.71 | GPR3 (0.40) | GPR3EPAS1PMM2MPIG6PD | |
| SCHEMBL767077 | 0.71 | GPR3 (0.40) | GPR3EPAS1RAB9AKDM4EALDH1A1 | |
| SCHEMBL66184 | 0.71 | GPR3 (0.40) | GPR3EPAS1PMM2MPIRAB9A | |
| SCHEMBL3525196 | 0.71 | EPHX2 (0.36) | GPR3PMM2MPIPHOSPHO1ALDH1A1 | |
| SCHEMBL3529744 | 0.69 | GPR3 (0.33) | GPR3 | |
| SCHEMBL2956882 | 0.68 | GPR3 (0.37) | GPR3EPAS1ALDH1A1LMNAHTT | |
| SCHEMBL3529881 | 0.68 | SMN1; SMN2 (0.33) | RAB9AKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL3526679 | 0.67 | GPR3 (0.36) | GPR3KDM4EALDH1A1MAPTCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8852937-B2 | Small organic molecule regulators of cell proliferation | CURIS, INC. (US) | 2014-10-07 | — | — | US | claimed |
| US-8129425-B2 | Contacting cell with hedgehog antagonist; moderator of cell proliferative, cell differentiation | CURIS, INC. (US) | 2012-03-06 | — | — | US | claimed |
| US-20060287385-A1 | Small organic molecule regulators of cell proliferation | CURIS, INC. | 2006-12-21 | — | — | US | claimed |
| US-7115653-B2 | Small organic molecule regulators of cell proliferation | CURIS, INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1436287-A4 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | CURIS INC (US) | 2005-10-26 | — | — | EP | claimed |
| US-20050070578-A1 | Small organic molecule regulators of cell proliferation | CURIS, INC. | 2005-03-31 | — | — | US | claimed |
| EP-1436287-A2 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | Curis, Inc. (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003027234-A9 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | CURIS INC (US) | 2004-02-19 | — | — | WO | claimed |
| US-6683192-B2 | SUBSTITUTED BENZO(B)THIEN COMPOUNDS USEFUL FOR MODULATING PROLIFERATION OR DIFFERENTIATION OF A CELL, AGONIZES HEDGEHOG MEDIATED SIGNAL TRASNDUCTION WITH AN ED50 OF 1MM OR LESS | CURIS, INC. | 2004-01-27 | — | — | US | claimed |
| US-20030139457-A1 | Small organic molecule regulators of cell proliferation | CURIS, INC. | 2003-07-24 | — | — | US | claimed |
| WO-2003027234-A2 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | CURIS, INC. (US) | 2003-04-03 | — | — | WO | claimed |
| US-20020198236-A1 | Small organic molecule regulators of cell proliferation | CURIS, INC. | 2002-12-26 | — | — | US | claimed |
| US-8852937-B2 | Small organic molecule regulators of cell proliferation | CURIS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20120269863-A1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | CURIS, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120245184-A1 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | ADERANS RESEARCH INSTITUTE, INC. | 2012-09-27 | — | — | US | disclosed |
| US-8273747-B2 | tert-Butyl (4-((4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino)-cyclohexyl)-methyl-carbamate; hedgehog pathway agonists; alopecia; angiogenesis; wound healing; alzheimer's disease; inhibit aging effects on skin | CURIS, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-4895587-A | Haloacetamide compounds, process for production thereof, and use thereof as herbicide | TOKUYAMA SODA KABUSHIKI KAISHA (JP) | 1990-01-23 | — | — | US | disclosed |
| EP-0206251-B1 | HALOACETAMIDE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF AS HERBICIDE | TOKUYAMA SODA KABUSHIKI KAISHA (JP) | 1988-09-07 | — | — | EP | disclosed |
| EP-0206251-A1 | Haloacetamide compounds, process for production thereof, and use thereof as herbicide | TOKUYAMA SODA KABUSHIKI KAISHA (JP) | 1986-12-30 | — | — | EP | disclosed |
| EP-0189774-A1 | Process for production of N,N-disubstituted carboxylic acid amides | TOKUYAMA SODA KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198236-A1 | Small organic molecule regulators of cell proliferation | GLI1, SHH, SMO | GPR3 476/4885EPAS1 1250/4885PMM2 4081/4885 |
| US-20120245184-A1 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | GLI1, SHH, SMO | GPR3 702/4885EPAS1 1025/4885PMM2 3436/4885 |
| US-20060287385-A1 | Small organic molecule regulators of cell proliferation | GLI1, SHH, SMO | GPR3 476/4885EPAS1 1250/4885PMM2 4081/4885 |
| US-20120269863-A1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | SHH, ICOS, SMO | GPR3 480/4885EPAS1 1037/4885PMM2 4518/4885 |
| US-20030139457-A1 | Small organic molecule regulators of cell proliferation | GLI1, SHH, SMO | GPR3 476/4885EPAS1 1250/4885PMM2 4081/4885 |
| US-20050070578-A1 | Small organic molecule regulators of cell proliferation | GLI1, SHH, SMO | GPR3 476/4885EPAS1 1250/4885PMM2 4081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.