SCHEMBL6594446

SCHEMBL6594446

Cc1cccc(NC(N)=S)c1.N#C[Na]

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.81
ALDH1A1 P00352 5/20 0.57
MAPT P10636 3/20 0.57
GAA P10253 2/20 0.57
KMT2A Q03164 3/20 0.53
MEN1 O00255 2/20 0.49
GRIN2D O15399 1/20 0.49
GRIN3B O60391 1/20 0.49
GRIN1 Q05586 1/20 0.49
GRIN2A Q12879 1/20 0.49
GRIN2B Q13224 1/20 0.49
GRIN2C Q14957 1/20 0.49
GRIN3A Q8TCU5 1/20 0.49
SIGMAR1 Q99720 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C19 P33261 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
HSD17B10 Q99714 2/20 0.49
TP53 P04637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1886408 0.90 CYP1A2 (1.00) CYP1A2ALDH1A1MAPTGAAKMT2A
SCHEMBL6983302 0.80 ALDH1A1 (0.50) CYP1A2ALDH1A1MAPTGAAKMT2A
SCHEMBL862993 0.77 CYP1A2 (0.75) CYP1A2ALDH1A1MAPTGAAKMT2A
SCHEMBL4047674 0.76 KMT2A (0.76) CYP1A2ALDH1A1MAPTGAAKMT2A
SCHEMBL8983422 0.75 MEN1 (0.58) CYP1A2ALDH1A1MAPTGAAKMT2A
SCHEMBL30557461 0.75 MEN1 (0.77) CYP1A2ALDH1A1MAPTGAAKMT2A
SCHEMBL9453941 0.75 MEN1 (0.77) CYP1A2ALDH1A1MAPTGAAKMT2A
SCHEMBL1884990 0.75 IDO1 (0.71) CYP1A2ALDH1A1MAPTGAAKMT2A
SCHEMBL6594447 0.74 MEN1 (0.56) CYP1A2ALDH1A1MAPTGAAKMT2A
Methane SCHEMBL9770392 0.73 CYP1A2 (0.69) CYP1A2ALDH1A1MAPTGAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1156803-A4 LACTAM INHIBITORS OF FXa AND METHOD BRISTOL MYERS SQUIBB CO (US) 2004-03-17 EP disclosed
EP-1156803-A1 LACTAM INHIBITORS OF FXa AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 2001-11-28 EP disclosed
WO-2000047207-A1 LACTAM INHIBITORS OF FXa AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 2000-08-17 WO disclosed