Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2536793 | 0.81 | GABRA1 (0.36) | GABRA1GABRB2 | |
| Water SCHEMBL10657212 | 0.77 | GABRA1 (0.45) | GABRA1GABRB2 | |
| SCHEMBL5822189 | 0.76 | GABRA1 (0.50) | GABRA1GABRB2 | |
| SCHEMBL7051562 | 0.76 | GABRA1 (0.33) | GABRA1GABRB2 | |
| SCHEMBL27365528 | 0.74 | — | — | |
| SCHEMBL11052 | 0.74 | GABRA1 (0.47) | GABRA1GABRB2 | |
| SCHEMBL3644895 | 0.73 | GABRA1 (0.32) | GABRA1GABRB2 | |
| SCHEMBL7361720 | 0.72 | — | — | |
| Iodide SCHEMBL11631414 | 0.72 | GABRA1 (0.45) | GABRA1GABRB2 | |
| SCHEMBL8359003 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |