Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 10/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MC5R | P33032 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | MC1R | Q01726 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594183 | 0.95 | TACR2 (0.41) | TACR2TACR1ACHE | |
| SCHEMBL6595395 | 0.91 | TACR2 (0.44) | TACR2MAPTLMNAALDH1A1TACR1 | |
| SCHEMBL6594752 | 0.89 | TACR2 (0.41) | TACR2MAPTLMNAALDH1A1TACR1 | |
| SCHEMBL6598857 | 0.86 | ALDH1A1 (0.45) | MAPTLMNAALDH1A1 | |
| SCHEMBL6597644 | 0.86 | LMNA (0.45) | TACR2MAPTLMNAALDH1A1TDP1 | |
| SCHEMBL6596565 | 0.86 | LMNA (0.43) | TACR2MAPTLMNAALDH1A1TACR1 | |
| SCHEMBL6599093 | 0.86 | TACR2 (0.46) | TACR2TACR1TSHR | |
| SCHEMBL6596004 | 0.85 | LMNA (0.43) | TACR2MAPTLMNAALDH1A1TACR1 | |
| SCHEMBL6607357 | 0.85 | LMNA (0.46) | TACR2MAPTLMNAALDH1A1TACR1 | |
| SCHEMBL6596830 | 0.85 | LMNA (0.44) | TACR2MAPTLMNAALDH1A1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888338-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2004-11-17 | — | — | EP | disclosed |