Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 12/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.34 |
| ▸ | GPR3 | P46089 | 2/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | IL1B | P01584 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602770 | 0.77 | CRHR1 (0.54) | CRHR1SCN9ARUNX1CTSA | |
| SCHEMBL4882797 | 0.77 | CRHR1 (0.56) | CRHR1SCN9A | |
| SCHEMBL4881389 | 0.77 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL4878756 | 0.77 | CRHR1 (0.55) | CRHR1SCN9ARUNX1GPR3 | |
| SCHEMBL4882896 | 0.76 | CRHR1 (0.60) | CRHR1SCN9A | |
| SCHEMBL4882817 | 0.74 | CRHR1 (0.59) | CRHR1SCN9ARUNX1GPR3 | |
| SCHEMBL6343532 | 0.74 | CRHR1 (0.55) | CRHR1SCN9ARUNX1GPR3IL1B | |
| SCHEMBL6356902 | 0.73 | CRHR1 (0.52) | CRHR1SCN9A | |
| SCHEMBL4882799 | 0.73 | CRHR1 (0.52) | CRHR1SCN9ARUNX1GPR3 | |
| SCHEMBL4879256 | 0.72 | CRHR1 (0.54) | CRHR1SCN9ACTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399428-A1 | 2,5-DIARYLPYRAZINES, 2,5-DIARYLPYRIDINES AND 2,5-DIARYLPYRIMIDINES AS CRF1 RECEPTOR MODULATORS | Neurogen Corporation (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2002100838-A1 | 2,5-DIARYLPYRAZINES, 2,5-DIARYLPYRIDINES AND 2,5-DIARYLPYRIMIDINES AS CRF1 RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2002-12-19 | — | — | WO | disclosed |