Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607143 | 0.91 | CRHR1 (0.54) | CRHR1SCN9ARUNX1NR1I2FFAR4 | |
| SCHEMBL6603304 | 0.89 | CRHR1 (0.46) | CRHR1SCN9ARUNX1NR1I2FFAR4 | |
| SCHEMBL6604201 | 0.87 | CRHR1 (0.49) | CRHR1SCN9ARUNX1NR1I2FFAR4 | |
| SCHEMBL6609362 | 0.83 | CRHR1 (0.46) | CRHR1SCN9ARUNX1NR1I2FFAR4 | |
| SCHEMBL5417192 | 0.82 | CRHR1 (0.62) | CRHR1SCN9ARUNX1 | |
| SCHEMBL4882896 | 0.82 | CRHR1 (0.60) | CRHR1SCN9A | |
| SCHEMBL6605395 | 0.80 | CRHR1 (0.54) | CRHR1SCN9ARUNX1NR1I2GRM7 | |
| SCHEMBL6205729 | 0.80 | CRHR1 (0.55) | CRHR1SCN9ARUNX1FFAR4FFAR1 | |
| SCHEMBL4881389 | 0.79 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL4882797 | 0.79 | CRHR1 (0.56) | CRHR1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392302-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096421-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2002-12-05 | — | — | WO | disclosed |