Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.52 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991961 | 0.94 | AGTR1 (0.59) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL28484414 | 0.88 | AGTR1 (0.59) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL9259068 | 0.87 | AGTR1 (0.52) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL1275437 | 0.86 | AGTR1 (0.55) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL991977 | 0.85 | AGTR1 (0.69) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL1966071 | 0.85 | AGTR1 (0.59) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| Potassium Ion SCHEMBL16872384 | 0.83 | AGTR1 (0.60) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL94332 | 0.83 | AGTR1 (0.74) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL992501 | 0.83 | AGTR1 (0.51) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL16872178 | 0.82 | AGTR1 (0.62) | AGTR1AGTR2ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1110551-B1 | Ocular tension lowering agent | SANKYO CO (JP) | 2004-05-12 | — | — | EP | disclosed |
| EP-0795326-B1 | OCULAR TENSION DEPRESSANT | SANKYO CO (JP) | 2001-09-26 | — | — | EP | disclosed |
| EP-1110551-A2 | Ocular tension lowering agent | Sankyo Company Limited (JP) | 2001-06-27 | — | — | EP | disclosed |
| US-5925664-A | VISION DEFECTS | SANKYO COMPANY, LIMITED (JP) | 1999-07-20 | — | — | US | disclosed |
| EP-0795326-A1 | OCULAR TENSION DEPRESSANT | SANKYO COMPANY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |