SCHEMBL65955

SCHEMBL65955

O=S(=O)(Cl)c1ccccc1C(F)(F)F

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
TRPV4 Q9HBA0 1/20 0.51
SLC22A12 Q96S37 14/20 0.50
RXFP1 Q9HBX9 1/20 0.46
HSD11B1 P28845 1/20 0.46
ALDH1A1 P00352 1/20 0.45
CYP2C9 P11712 2/20 0.44
SLC22A6 Q4U2R8 2/20 0.44
SLC22A8 Q8TCC7 2/20 0.44
SLC22A11 Q9NSA0 2/20 0.44
KAT6A Q92794 1/20 0.43
CYP3A4 P08684 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29500393 1.00 MEN1 (0.56) MEN1KMT2ATRPV4SLC22A12RXFP1
SCHEMBL23850769 0.83 MEN1 (0.53) MEN1KMT2ASLC22A12RXFP1HSD11B1
SCHEMBL29874131 0.82 MEN1 (0.60) MEN1KMT2ASLC22A12RXFP1HSD11B1
SCHEMBL3625928 0.82 MEN1 (0.60) MEN1KMT2ASLC22A12RXFP1HSD11B1
SCHEMBL17850502 0.82 TRPV4 (0.44) MEN1KMT2ATRPV4SLC22A12RXFP1
SCHEMBL29434897 0.82 CCR4 (0.44) MEN1KMT2ATRPV4SLC22A12RXFP1
SCHEMBL6240708 0.82 CCR4 (0.44) MEN1KMT2ATRPV4SLC22A12RXFP1
SCHEMBL5162463 0.82 TRPV4 (0.44) MEN1KMT2ATRPV4SLC22A12RXFP1
SCHEMBL27958458 0.81 MEN1 (0.48) MEN1KMT2ATRPV4SLC22A12RXFP1
SCHEMBL11248862 0.80 TRPV4 (0.42) MEN1KMT2ATRPV4SLC22A12RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118307615-A Paeoniflorin derivative with antioxidant activity and synthesis method thereof 黑龙江中医药大学 2024-07-09 CN claimed
CN-116814325-A Cutting fluid for aluminum alloy and preparation method thereof 山东创新金属科技有限公司 2023-09-29 CN claimed
CN-217616372-U Raw material washing device is used in production of trifluoromethyl benzene sulfonyl chloride 内蒙古蓝科生物科技有限公司 2022-10-21 CN claimed
CN-109608369-B Sulfonyl ester group anthraquinone derivative and preparation method and application thereof 广西大学 2021-04-09 CN claimed
CN-109608369-A Sulphonyl ester group anthraquinone derivatives and its preparation method and application 广西大学 2019-04-12 CN claimed
US-10125226-B2 Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils INSTITUTO MEXICANO DEL PETROLEO (MX) 2018-11-13 US claimed
US-20140364566-A1 SCALE-UP PROCESS OF BIFUNCTIONALIZED TRIBLOCK COPOLYMERS WITH SECONDARY AND TERTIARY AMINES, WITH APPLICATION IN DEWATERING AND DESALTING OF HEAVY CRUDE OILS INSTITUTO MEXICANO DEL PETROLEO (MX) 2014-12-11 US claimed
CN-102603630-A O-aminobenzoic acid sulfonylation derivative as well as preparation method and application thereof UNIV BEIJING SCIENCE & TECH 2012-07-25 CN claimed
EP-2385831-A2 SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT The UAB Research Foundation (US) 2011-11-16 EP claimed
US-20110254866-A1 INFORMATION PROCESSING APPARATUS, METHOD AND PROGRAM THEREFORE SONY CORPORATION (JP) 2011-10-20 US claimed
WO-2011045807-A2 A NOVEL PROCESS TO MANUFACTURE (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL NEULAND LABORATORIES LTD. (IN) 2011-04-21 WO claimed
WO-2010123591-A2 SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT THE UAB RESEARCH FOUNDATION (US) 2010-10-28 WO claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 EP claimed
JP-1156953-A None JP disclosed
JP-1272566-A None JP disclosed
CN-119320374-B Method for synthesizing 3-sulfonyl substituted chromone derivative by photocatalysis JIANG University OF TECHNOLOGY (CN) 2026-05-26 CN disclosed
EP-0027906-B1 PROCESS FOR PREPARING SULPHON AMIDES BAYER AG (DE) 1983-05-25 EP disclosed
EP-0027906-A1 Process for preparing sulphon amides BAYER AG (DE) 1981-05-06 EP disclosed
US-4159331-A Antihypertensive 4-aminoquinolines THE UPJOHN COMPANY (US) 1979-06-26 US disclosed
US-4060549-A Process for preparing sulfonic acid fluorides BAYER AKTIENGESELLSCHAFT (DT) 1977-11-29 US disclosed