Trifluoromethylbenzene

Trifluoromethylbenzene

SCHEMBL65956

FC(F)(F)c1ccccc1.O=S(=O)(Cl)Cl

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.70
TSHR P16473 2/20 0.70
KIF11 P52732 2/20 0.52
CA1 P00915 4/20 0.52
CA2 P00918 4/20 0.52
CA9 Q16790 2/20 0.52
CA5A P35218 1/20 0.52
HSD11B1 P28845 2/20 0.44
HSD17B10 Q99714 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
BACE1 P56817 1/20 0.44
TRPV6 Q9H1D0 1/20 0.43
PTPN1 P18031 1/20 0.43
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 2/20 0.42
HTT P42858 2/20 0.42
LMNA P02545 1/20 0.42
CYP19A1 P11511 1/20 0.41
ACP3 P15309 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethylbenzene SCHEMBL28303314 1.00 ALDH1A1 (0.70) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL28221710 0.98 ALDH1A1 (0.67) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL6018790 0.91 ALDH1A1 (0.64) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL4616496 0.87 ALDH1A1 (0.74) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL28194912 0.86 ALDH1A1 (0.52) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL27721404 0.85 TSHR (0.70) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL4867878 0.84 TSHR (0.88) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL175647 0.84 TSHR (1.00) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL8692 0.84 TSHR (1.00) ALDH1A1TSHRKIF11CA1CA2
Trifluoromethylbenzene SCHEMBL27760126 0.84 TSHR (1.00) ALDH1A1TSHRKIF11CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 705 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024006773-A1 METHODS OF PREPARING HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS CORCEPT THERAPEUTICS INCORPORATED (US) 2024-01-04 WO claimed
CN-115490622-A Trifluoromethyl thiophenol compound 上海泰初化工技术有限公司 2022-12-20 CN claimed
CN-111499540-B Method for preparing 2,4,6-trichlorobenzonitrile by ammoxidation method, special catalyst and preparation method 中南民族大学 2022-09-27 CN claimed
CN-114656436-A Flavonol sulfonate photo-acid generator and preparation method thereof 安庆北化大科技园有限公司 2022-06-24 CN claimed
CN-111620760-B Method for preparing 2,3,5, 6-tetrachlorobenzonitrile 中南民族大学 2022-05-24 CN claimed
CN-109608369-B Sulfonyl ester group anthraquinone derivative and preparation method and application thereof 广西大学 2021-04-09 CN claimed
CN-109336795-B Preparation method of 3-trifluoromethylthiophenol and 3-methylthio benzotrifluoride 利尔化学股份有限公司 2020-12-25 CN claimed
CN-110105255-B Mild synthesis method of diaryl thioether 江西理工大学 2020-11-03 CN claimed
CN-111620760-A Method for preparing 2,3,5, 6-tetrachlorobenzonitrile, special catalyst and preparation method 中南民族大学 2020-09-04 CN claimed
CN-111499540-A Method for preparing 2,4,6-trichlorobenzonitrile by ammoxidation method, special catalyst and preparation method 中南民族大学 2020-08-07 CN claimed
CN-104678028-A Pretreatment and detection method for biogen amine neurotransmitter and detection kit INST PHARM & TOXICOLOGY AMMS 2015-06-03 CN claimed
CN-103265436-B Method for synthesising 1,5,9-trinitro-2,3,6,7,10,11-hexa-alkoxy triphenylene UNIV SHAANXI NORMAL 2015-03-18 CN claimed
CN-103898515-A Corrosion inhibitor for gas field and preparation method thereof CHINA NAT PETROLEUM CORP 2014-07-02 CN claimed
CN-103694170-A Synthetic method of 6,7-difluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride CHANGZHOU XIAQING CHEMICAL CO LTD 2014-04-02 CN claimed
CN-103265436-A Method for synthesising 1,5,9-trinitro-2,3,6,7,10,11-hexa-alkoxy triphenylene UNIV SHAANXI NORMAL 2013-08-28 CN claimed
CN-101973916-B Method for regulating orinase officinal superior crystal form by functionalized self-assembled film UNIV TIANJIN 2013-04-10 CN claimed
CN-102603630-A O-aminobenzoic acid sulfonylation derivative as well as preparation method and application thereof UNIV BEIJING SCIENCE & TECH 2012-07-25 CN claimed
CN-102531978-A Preparation method of thiophenol UNIV ZHEJIANG 2012-07-04 CN claimed
CN-102336689-A Preparation and refining method of 4-Cl-(trifluoromethyl) benzene sulfonyl chloride JUNKAI TIANJIN CHEMICAL CO LTD 2012-02-01 CN claimed
CN-101973916-A Method for regulating orinase officinal superior crystal form by functionalized self-assembled film UNIV TIANJIN 2011-02-16 CN claimed