Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596120 | 0.93 | CCR2 (0.58) | CCR2TSHRCYP2D6ABCB11POLB | |
| SCHEMBL6591954 | 0.82 | CCR2 (0.55) | CCR2ABCB11KMT2A | |
| SCHEMBL6595314 | 0.81 | CCR2 (0.54) | CCR2ABCB11KMT2A | |
| SCHEMBL6600137 | 0.80 | CCR2 (0.57) | CCR2ABCB11HPGD | |
| SCHEMBL6594667 | 0.77 | CCR2 (0.61) | CCR2ABCB11 | |
| SCHEMBL6594432 | 0.74 | CCR2 (0.68) | CCR2ABCB11 | |
| SCHEMBL6598242 | 0.74 | CCR2 (0.57) | CCR2CCR3KMT2AALDH1A1 | |
| SCHEMBL6595648 | 0.73 | CCR2 (0.66) | CCR2ABCB11 | |
| SCHEMBL6591932 | 0.72 | CCR2 (0.64) | CCR2ABCB11KMT2A | |
| SCHEMBL6596843 | 0.71 | CCR2 (0.65) | CCR2ABCB11KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150954-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| US-6569888-B1 | Such as ethyl-N-(dichlorobenzyl)-4-(3-hydroxypropylthio) indole-2-carboxylate; for treatment of arthritis | ASTRAZENECA AB (SE) | 2003-05-27 | — | — | US | disclosed |
| EP-1150954-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046198-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |