Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595648 | 0.92 | CCR2 (0.66) | CCR2ABCB11 | |
| SCHEMBL6591954 | 0.84 | CCR2 (0.55) | CCR2ABCB11 | |
| SCHEMBL6595314 | 0.83 | CCR2 (0.54) | CCR2ABCB11 | |
| SCHEMBL6596120 | 0.82 | CCR2 (0.58) | CCR2ABCB11 | |
| SCHEMBL6308101 | 0.81 | CCR2 (1.00) | CCR2ABCB11 | |
| SCHEMBL6600137 | 0.78 | CCR2 (0.57) | CCR2ABCB11 | |
| SCHEMBL6303492 | 0.77 | CCR2 (0.74) | CCR2ABCB11 | |
| SCHEMBL6596985 | 0.76 | ABCB11 (0.78) | CCR2ABCB11 | |
| SCHEMBL6594667 | 0.75 | CCR2 (0.61) | CCR2ABCB11 | |
| SCHEMBL6595640 | 0.74 | CCR2 (0.48) | CCR2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150954-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| US-6569888-B1 | Such as ethyl-N-(dichlorobenzyl)-4-(3-hydroxypropylthio) indole-2-carboxylate; for treatment of arthritis | ASTRAZENECA AB (SE) | 2003-05-27 | — | — | US | disclosed |
| EP-1150954-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046198-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |