SCHEMBL6595670

SCHEMBL6595670

C=CCC(C(=O)O)=C(C)N

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.33
ALDH1A1 P00352 2/20 0.32
TSHR P16473 1/20 0.32
FGFR4 P22455 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
LMNA P02545 1/20 0.30
ALOX15 P16050 1/20 0.30
BLM P54132 1/20 0.30
PMP22 Q01453 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6595665 1.00 GRIK1 (0.33) GRIK1ALDH1A1TSHRFGFR4TDP1
SCHEMBL8760520 0.81 ALDH1A1 (0.35) ALDH1A1TSHRFGFR4LMNA
SCHEMBL8570759 0.81 ALDH1A1 (0.35) ALDH1A1TSHRFGFR4LMNA
SCHEMBL28268445 0.81 GRIK1 (0.40) GRIK1ALDH1A1LMNA
SCHEMBL1644504 0.81 ALDH1A1 (0.35) GRIK1ALDH1A1LMNA
SCHEMBL815174 0.80 LMNA (0.37) ALDH1A1TSHRTDP1LMNAALOX15
SCHEMBL815175 0.80 LMNA (0.37) ALDH1A1TSHRTDP1LMNAALOX15
SCHEMBL3903875 0.80 LMNA (0.37) ALDH1A1TSHRTDP1LMNAALOX15
SCHEMBL1135817 0.79 FNTA (0.42) GRIK1ALDH1A1ALOX15
SCHEMBL10901739 0.79 ALDH1A1 (0.33) GRIK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0176053-B1 1,4-DIHYDROPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM POLI INDUSTRIA CHIMICA S.p.A. (IT) 1989-01-18 EP claimed
US-6689799-B1 NON-NUCLEOSIDE-DERIVATIVE VIRICIDES REPHARTOX (NL) 2004-02-10 US disclosed
EP-1214315-B9 1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID ESTER DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF REPHARTOX (NL) 2004-01-02 EP disclosed
EP-1214315-B1 1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID ESTER DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF REPHARTOX (NL) 2003-05-02 EP disclosed
EP-1214315-A1 1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID ESTER DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF Rephartox (NL) 2002-06-19 EP disclosed
WO-2001014370-A1 1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID ESTER DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF REPHARTOX (NL) 2001-03-01 WO disclosed
US-6084029-A POLYOLEFINS GRAFTED WITH AN UNSATURATED CARBOXYLIC ACID AND/OR AN UNSATURATED CARBOXYLIC ACID ANHYDRIDE AND A POLYMERIC OR OLIGOMERIC POLYAMINE, FOR EXTRUSION OR CASTING THE DOW CHEMICAL COMPANY (US) 2000-07-04 US disclosed