Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16975488 | 0.86 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL694999 | 0.86 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL30780892 | 0.86 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL10340437 | 0.84 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL16975448 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL14768876 | 0.82 | ALDH1A1 (0.64) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL10175659 | 0.82 | ALDH1A1 (0.64) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL28744999 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TDP1TSHRCYP3A4PDE2A | |
| SCHEMBL5598378 | 0.81 | GSK3B (0.43) | ALDH1A1TDP1TSHRCYP3A4HSD17B10 | |
| SCHEMBL29001898 | 0.79 | HSD17B10 (0.43) | ALDH1A1TDP1TSHRCYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102194-A1 | BETA-SUBSTITUTED GAMMA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS | Quadriga Biosciences, Inc. (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015117146-A1 | BETA-SUBSTITUTED GAMMA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS | QUADRIGA BIOSCIENCES, INC. (US) | 2015-08-06 | — | — | WO | disclosed |
| CN-101981036-B | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2013-09-04 | — | — | CN | disclosed |
| US-6743809-B2 | Indole Derivatives useful for the treatment of CNS disorders | H. LUNDBECK A/S (DK) | 2004-06-01 | — | — | US | disclosed |
| EP-1305307-B1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | LUNDBECK & CO AS H (DK) | 2004-05-06 | — | — | EP | disclosed |
| US-20030166664-A1 | Indole derivatives useful for the treatment of CNS disorders | H. LUNDBECK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| EP-1305307-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. Lundbeck A/S (DK) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002008223-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166664-A1 | Indole derivatives useful for the treatment of CNS disorders | DRD2, DRD3, CNR1 | ALDH1A1 815/4885TDP1 1971/4885TSHR 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.