Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 5/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160148 | 0.72 | MEN1 (0.46) | NR1H2MEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL12217740 | 0.68 | NR1H2 (0.48) | NR1H2GRM5GRM1PDK4MEN1 | |
| SCHEMBL17304324 | 0.68 | NR1H2 (0.48) | NR1H2GRM5GRM1PDK4MEN1 | |
| SCHEMBL6334689 | 0.67 | NR1H2 (0.34) | NR1H2GRM5GRM1PDK4GPR119 | |
| Hydrochloric Acid SCHEMBL6596950 | 0.66 | CCNT1 (0.30) | — | |
| SCHEMBL31639554 | 0.66 | NR1H2 (0.45) | NR1H2GRM5MEN1MAPTKMT2A | |
| SCHEMBL31639550 | 0.66 | NR1H2 (0.45) | NR1H2GRM5MEN1MAPTKMT2A | |
| SCHEMBL16422734 | 0.65 | HDAC2 (0.43) | GRM5GRM1MEN1KMT2ARORC | |
| SCHEMBL31279269 | 0.65 | NR1H2 (0.45) | NR1H2GRM5GRM1PDK4MEN1 | |
| SCHEMBL30872426 | 0.64 | NR1H2 (0.43) | NR1H2GRM5GRM1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204660-B1 | SEROTONERGIC BENZOTHIOPHENES | LILLY CO ELI (US) | 2004-10-20 | — | — | EP | disclosed |