Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | GYS1 | P13807 | 4/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.32 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 3/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6330870 | 0.74 | GYS1 (0.36) | NR1H2PDK4GYS1CDK9CCNT1 | |
| SCHEMBL9933603 | 0.70 | PDK4 (0.51) | PDK4CDK9CCNT1EEDRBBP4 | |
| SCHEMBL6339270 | 0.70 | GYS1 (0.37) | NR1H2PDK4GYS1CDK9CCNT1 | |
| SCHEMBL2160148 | 0.68 | MEN1 (0.46) | NR1H2 | |
| SCHEMBL6332970 | 0.68 | GPR119 (0.40) | JAK1GPR119 | |
| SCHEMBL6331202 | 0.68 | GPR119 (0.40) | JAK1GPR119 | |
| SCHEMBL6332967 | 0.68 | GPR119 (0.40) | JAK1GPR119 | |
| SCHEMBL6331203 | 0.68 | GPR119 (0.40) | JAK1GPR119 | |
| SCHEMBL6331201 | 0.68 | GPR119 (0.40) | JAK1GPR119 | |
| SCHEMBL6596592 | 0.67 | NR1H2 (0.35) | NR1H2PDK4GRM5GRM1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881733-B1 | Serotonergic benzofurans | ELI LILLY AND COMPANY (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1204659-B1 | SEROTONERGIC BENZOFURANS | LILLY CO ELI (US) | 2003-11-26 | — | — | EP | disclosed |