SCHEMBL659686

SCHEMBL659686

O=C(CCc1ccc(Cl)cc1)c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.64
GPR84 Q9NQS5 2/20 0.63
NPC1 O15118 3/20 0.59
RAB9A P51151 3/20 0.59
TDP1 Q9NUW8 2/20 0.59
CASP3 P42574 1/20 0.59
SENP8 Q96LD8 1/20 0.59
SENP7 Q9BQF6 1/20 0.59
SENP6 Q9GZR1 1/20 0.59
L3MBTL1 Q9Y468 4/20 0.58
MAPT P10636 3/20 0.58
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
HPGD P15428 1/20 0.55
PLAAT3 P53816 3/20 0.54
PLAAT5 Q96KN8 3/20 0.54
PLAAT2 Q9NWW9 3/20 0.54
PLAAT4 Q9UL19 3/20 0.54
HSD11B1 P28845 3/20 0.54
CES2 O00748 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3078714 0.93 L3MBTL1 (0.68) PDPK1GPR84NPC1RAB9ATDP1
SCHEMBL11123550 0.90 GPR84 (0.59) PDPK1GPR84NPC1RAB9AL3MBTL1
SCHEMBL656028 0.90 FFAR1 (0.59) PDPK1GPR84NPC1RAB9AL3MBTL1
SCHEMBL15524969 0.86 TDP1 (0.77) NPC1RAB9ATDP1CASP3SENP8
SCHEMBL30572 0.86 TDP1 (0.77) NPC1RAB9ATDP1CASP3SENP8
SCHEMBL28251466 0.86 TDP1 (0.77) NPC1RAB9ATDP1CASP3SENP8
SCHEMBL17492459 0.84 GPR84 (0.58) PDPK1GPR84TDP1MAPTKMT2A
SCHEMBL28372673 0.84 L3MBTL1 (0.72) NPC1RAB9ATDP1L3MBTL1MAPT
Hydrochloric Acid SCHEMBL27556767 0.84 TDP1 (0.74) NPC1RAB9ATDP1CASP3SENP8
SCHEMBL11431321 0.84 NPC1 (0.69) GPR84NPC1RAB9ATDP1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116199597-A Substituted phenyl diazonium salt and application thereof in catalytic preparation of 3-substituted indole compounds 盐城利民农化有限公司 2023-06-02 CN claimed
CN-112569936-A Novel metal-doped catalyst for selectively synthesizing bisphenol F, and preparation method and application thereof 江南大学 2021-03-30 CN claimed
CN-116102430-B Alkylation synthesis method for in-situ catalytic alcohols 中山大学 2025-03-14 CN disclosed
WO-2023149559-A1 CATALYST FOR HYDROGENATION REACTIONS, METHOD FOR PRODUCING SAME AND METHOD FOR PRODUCING HYDROGENATED ORGANIC COMPOUND エヌ・イーケムキャット株式会社 2023-08-10 WO disclosed
CN-116102430-A Alkylation synthesis method for in-situ catalytic alcohols 中山大学 2023-05-12 CN disclosed
CN-112047797-B Method for preparing alpha-alkyl substituted ketone compound 赣南医学院 2023-04-07 CN disclosed
CN-111807971-B Alkylation synthesis method for in-situ catalysis of alcohols 中山大学 2023-03-24 CN disclosed
CN-112569936-B Novel metal-doped catalyst for selectively synthesizing bisphenol F, and preparation method and application thereof 江南大学 2022-04-15 CN disclosed
CN-111499503-B Method for synthesizing alpha-alkylated ketone in water 南京理工大学 2022-04-08 CN disclosed
CN-112354565-B Graphene oxide supported ruthenium catalyst and preparation method and application thereof 江南大学 2021-10-22 CN disclosed
CN-112569936-A Novel metal-doped catalyst for selectively synthesizing bisphenol F, and preparation method and application thereof 江南大学 2021-03-30 CN disclosed
CN-105906543-A Novel synthesis method of multifunctional pyrrole 常州大学 2016-08-31 CN disclosed
CN-104557500-B A kind of method of synthetic alpha-alkyl ketone NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2016-05-18 CN disclosed
CN-105439787-A Method for synthesizing alpha-alkyl ketone UNIV NANJING SCIENCE & TECH 2016-03-30 CN disclosed
EP-2349999-B1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIV SAARLAND (DE) 2016-01-27 EP disclosed
CN-104557500-A Method for synthesizing alpha-alkyl ketone UNIV NANJING SCIENCE & TECH 2015-04-29 CN disclosed
US-8912186-B2 Allosteric protein kinase modulators UNIVERSITAET DES SAARLANDES (DE) 2014-12-16 US disclosed
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2012-02-23 US disclosed
CN-102351675-A Preparation process of 4-chlorophenyl benzyl ketone UNIV CHANGZHOU 2012-02-15 CN disclosed
EP-2177510-A1 Allosteric protein kinase modulators Universität des Saarlandes (DE) 2010-04-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS AURKC, AURKA, AURKB PDPK1 109/4885GPR84 3246/4885NPC1 2687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.