Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598829 | 0.85 | ALDH1A1 (0.41) | ALDH1A1ELANEPOLBRAB9AHTT | |
| SCHEMBL31013552 | 0.83 | CHRNB2 (0.48) | KMT2A | |
| SCHEMBL23356900 | 0.79 | DPP4 (0.49) | ALDH1A1ELANEPOLBRAB9AHTT | |
| SCHEMBL2016284 | 0.79 | DPP4 (0.49) | ALDH1A1ELANEPOLBRAB9AHTT | |
| SCHEMBL4447785 | 0.79 | DPP4 (0.49) | ALDH1A1ELANEPOLBRAB9AHTT | |
| Hydrochloric Acid SCHEMBL10521985 | 0.77 | DPP4 (0.50) | ALDH1A1ELANEPOLBRAB9AHTT | |
| SCHEMBL12319362 | 0.77 | CNR2 (0.37) | ELANECNR2MAPTPKMLTA4H | |
| SCHEMBL27372387 | 0.77 | TSHR (0.54) | ALDH1A1MAPTPKMKMT2ATDP1 | |
| SCHEMBL6593799 | 0.76 | ALDH1A1 (0.40) | ALDH1A1ELANEPOLBRAB9AHTT | |
| SCHEMBL5813373 | 0.75 | ELANE (0.51) | ELANEMAPTPKMPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228061-A4 | DIPEPTIDYL PEPTIDASE IV INHIBITORS AND METHODS OF MAKING AND USING DIPEPTIDYL PEPTIDASE IV INHIBITORS | GUILFORD PHARM INC (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1228061-A1 | DIPEPTIDYL PEPTIDASE IV INHIBITORS AND METHODS OF MAKING AND USING DIPEPTIDYL PEPTIDASE IV INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001034594-A1 | DIPEPTIDYL PEPTIDASE IV INHIBITORS AND METHODS OF MAKING AND USING DIPEPTIDYL PEPTIDASE IV INHIBITORS | GUILFORD PHARMACEUTICALS, INC. (US) | 2001-05-17 | — | — | WO | disclosed |