Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27901751 | 0.94 | LMNA (0.40) | LMNATDP1LTA4HCNR2ALDH1A1 | |
| SCHEMBL11410075 | 0.89 | TSHR (0.45) | LMNATDP1TSHRSMN1; SMN2LTA4H | |
| SCHEMBL27293430 | 0.84 | LMNA (0.34) | LMNASMN1; SMN2PPARGPPARA | |
| SCHEMBL489041 | 0.81 | HDAC3 (0.41) | LMNATSHREGFRHDAC3 | |
| SCHEMBL10497298 | 0.77 | LMNA (0.45) | LMNATDP1TSHRCNR2POLB | |
| SCHEMBL4299524 | 0.77 | EGFR (0.41) | LMNATDP1SMN1; SMN2CNR2EGFR | |
| SCHEMBL236417 | 0.75 | EGFR (0.43) | LMNATDP1SMN1; SMN2ALDH1A1EGFR | |
| SCHEMBL10703015 | 0.75 | EGFR (0.43) | LMNATDP1SMN1; SMN2ALDH1A1EGFR | |
| SCHEMBL4612716 | 0.75 | EGFR (0.43) | LMNATDP1SMN1; SMN2ALDH1A1EGFR | |
| SCHEMBL2332472 | 0.74 | LMNA (0.39) | LMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414444-A1 | NOVEL IMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VLA-4 ANTAGONISTS | Aventis Pharma Deutschland GmbH (DE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003011288-A1 | NOVEL IMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VLA-4 ANTAGONISTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-02-13 | — | — | WO | disclosed |