Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | REN | P00797 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | PSMB10 | P40306 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 6/20 | 0.51 |
| ▸ | PSMB9 | P28065 | 5/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347958 | 1.00 | BCL2 (0.59) | BCL2PTPN1HDAC8MMP9MMP8 | |
| SCHEMBL5347955 | 1.00 | BCL2 (0.59) | BCL2PTPN1HDAC8MMP9MMP8 | |
| SCHEMBL1204211 | 0.90 | JAK3 (0.61) | HDAC8RENJAK3BTKCTSS | |
| SCHEMBL6557659 | 0.90 | JAK3 (0.61) | HDAC8RENJAK3BTKCTSS | |
| SCHEMBL9052038 | 0.87 | ACE (0.64) | PTPN1JAK3BTKITGB3ITGA2B | |
| SCHEMBL8185213 | 0.87 | CTSS (0.62) | BCL2PTPN1HDAC8JAK3BTK | |
| SCHEMBL9929886 | 0.87 | CTSS (0.62) | BCL2PTPN1HDAC8JAK3BTK | |
| SCHEMBL6161729 | 0.86 | BCL2 (0.64) | BCL2PTPN1HDAC8RENITGB3 | |
| SCHEMBL3500186 | 0.86 | BCL2 (0.64) | BCL2PTPN1HDAC8RENITGB3 | |
| SCHEMBL3350988 | 0.86 | BCL2 (0.64) | BCL2PTPN1HDAC8RENITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110040087-A1 | PEPTIDE TURN MIMETICS | MIMETICA PTY LTD. (AU) | 2011-02-17 | — | — | US | disclosed |
| EP-1081132-B1 | HYDROXAMIC ACID DERIVATIVES AND MEDICINAL UTILIZATION THEREOF | MITSUBISHI PHARMA CORP (JP) | 2004-03-10 | — | — | EP | disclosed |
| US-6610729-B1 | Inhibotors of TNF, antiinflammatory | MITSUBISHI PHARMA CORPORATION (JP) | 2003-08-26 | — | — | US | disclosed |
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1081132-A1 | HYDROXAMIC ACID DERIVATIVES AND MEDICINAL UTILIZATION THEREOF | Welfide Corporation (JP) | 2001-03-07 | — | — | EP | disclosed |
| EP-0742791-B1 | MACROCYCLIC DIFLUOROSTATONE DERIVATIVES USEFUL AS ANTIVIRAL AGENTS | MERRELL PHARMA INC (US) | 2001-01-10 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5969132-A | Macrocyclic difluorostatone derivatives useful as antiviral agents | MERRELL PHARMACEUTICALS INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5716973-A | ADMINISTERING DIFLUORO STATONE ANALOGS | MERRELL PHARMACEUTICALS INC. (US) | 1998-02-10 | — | — | US | disclosed |
| US-5559140-A | VIRICIDES | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-24 | — | — | US | disclosed |
| WO-1996002499-A1 | DIFLUOROSTATONE ANTIVIRAL AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1996-02-01 | — | — | WO | disclosed |
| US-5455271-A | Using aromatic amine derivitives as mosquito insecticide | THE SCRIPPS RESEARCH INSTITUTE (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1995021186-A1 | MACROCYCLIC DIFLUOROSTATONE DERIVATIVES USEFUL AS ANTIVIRAL AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-10 | — | — | WO | disclosed |
| WO-1995009838-A1 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| WO-1994000420-A1 | NOVEL TIGHT-BINDING INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 1994-01-06 | — | — | WO | disclosed |
| EP-0565631-A1 | ANTI-VIRAL COMPOUNDS. | MERRELL DOW PHARMA (US) | 1993-10-20 | — | — | EP | disclosed |
| WO-1992012123-A1 | ANTI-VIRAL COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-23 | — | — | WO | disclosed |
| EP-0434365-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| WO-1990000399-A1 | RETROVIRAL PROTEASE BINDING PEPTIDES | SMITHKLINE BECKMAN CORPORATION (US) | 1990-01-25 | — | — | WO | disclosed |
| EP-0352000-A2 | Retroviral protease binding peptides | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110040087-A1 | PEPTIDE TURN MIMETICS | VIP, IAPP, SCTR | BCL2 4163/4885PTPN1 2173/4885HDAC8 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.