Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 17/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.71 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599719 | 0.86 | CCR2 (0.70) | CCR2ABCB11 | |
| SCHEMBL2006351 | 0.84 | CCR2 (0.79) | CCR2ABCB11F10 | |
| SCHEMBL6592482 | 0.83 | CCR2 (1.00) | CCR2ABCB11 | |
| SCHEMBL2002926 | 0.81 | CCR2 (0.74) | CCR2ABCB11F10 | |
| SCHEMBL6597871 | 0.80 | CCR2 (0.80) | CCR2ABCB11F10 | |
| SCHEMBL5681475 | 0.80 | CCR2 (0.82) | CCR2ABCB11F10 | |
| SCHEMBL2005378 | 0.78 | CCR2 (0.73) | CCR2ABCB11F10 | |
| SCHEMBL6597097 | 0.78 | CCR2 (0.80) | CCR2ABCB11F10 | |
| SCHEMBL7086878 | 0.78 | CCR2 (0.80) | CCR2ABCB11F10 | |
| SCHEMBL5679145 | 0.77 | CCR2 (0.75) | CCR2ABCB11F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |