Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598356 | 0.83 | GRIA1 (0.42) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6599634 | 0.82 | MAPT (0.37) | — | |
| SCHEMBL6597213 | 0.73 | GRIA1 (0.42) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6605093 | 0.72 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6596409 | 0.72 | GRIA1 (0.57) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6603908 | 0.72 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6598151 | 0.71 | FPR2 (0.39) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6596000 | 0.71 | GRIA1 (0.56) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6594056 | 0.70 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6597729 | 0.70 | GRIA1 (0.67) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156044-B1 | 6-SUBSTITUTED HETEROQUINOLINECARBOXYLIC ACID DERIVATIVES AND ADDITION SALTS THEREOF AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN SEIYAKU KK (JP) | 2004-08-25 | — | — | EP | disclosed |
| US-6562839-B1 | Effective for the therapy of disorder of cerebral nerve cells as antagonists against excitatory amino acid receptors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2003-05-13 | — | — | US | disclosed |
| EP-1156044-A1 | 6-SUBSTITUTED HETEROQUINOLINECARBOXYLIC ACID DERIVATIVES AND ADDITION SALTS THEREOF AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2001-11-21 | — | — | EP | disclosed |