Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18888757 | 0.95 | NPC1 (0.41) | NPC1CRBNDDB1ALDH1A1L3MBTL1 | |
| SCHEMBL10794652 | 0.93 | ALDH1A1 (0.42) | NPC1CRBNDDB1ALDH1A1L3MBTL1 | |
| SCHEMBL10489330 | 0.93 | ALDH1A1 (0.42) | NPC1CRBNDDB1ALDH1A1L3MBTL1 | |
| SCHEMBL24756756 | 0.93 | ALDH1A1 (0.42) | NPC1CRBNDDB1ALDH1A1L3MBTL1 | |
| SCHEMBL13007383 | 0.89 | MAP3K14 (0.38) | NPC1CRBNDDB1ALDH1A1L3MBTL1 | |
| SCHEMBL15606251 | 0.81 | MAP3K14 (0.40) | NPC1CRBNDDB1MAP3K14HDAC8 | |
| SCHEMBL11886046 | 0.79 | MAP3K14 (0.33) | CRBNDDB1MAP3K14LMNAMAPT | |
| SCHEMBL10029440 | 0.78 | MAP3K14 (0.38) | NPC1CRBNDDB1ALDH1A1MAP3K14 | |
| SCHEMBL9247739 | 0.78 | POLB (0.40) | NPC1CRBNDDB1ALDH1A1MAP3K14 | |
| SCHEMBL13892184 | 0.76 | SMN1; SMN2 (0.36) | NPC1CRBNDDB1MAP3K14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1201664-B1 | BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME | FUJI PHOTO FILM CO LTD (JP) | 2004-09-08 | — | — | EP | disclosed |
| US-6593323-B1 | Benzimidazole compound inhibitory action of forming of macrophages and is useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of arteriosclerosis, which is represented by the formula (I): | FUJI PHOTO FILM CO., LTD. (JP) | 2003-07-15 | — | — | US | disclosed |
| EP-1201664-A1 | BENZIMIDAZOLE COMPOUNDS AND DRUGS CONTAINING THE SAME | FUJI PHOTO FILM CO., LTD. (JP) | 2002-05-02 | — | — | EP | disclosed |
| US-4874874-A | REACTING SULFENYLSUCCINIMIDE WITH HYDROGEN PEROXIDE IN ACID SOLVENT | BAYER AKTIENGESELLSCHAFT (DE) | 1989-10-17 | — | — | US | disclosed |
| EP-0269837-A2 | Process for the preparation of 3-sulfenylmaleimides and their use | BAYER AG (DE) | 1988-06-08 | — | — | EP | disclosed |