Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 7/20 | 0.47 |
| ▸ | CTSK | P43235 | 6/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595585 | 0.85 | CTSS (0.50) | PPARGPPARACTSSCTSKCTSL | |
| SCHEMBL8094669 | 0.85 | CTSS (0.50) | PPARGPPARACTSSCTSKCTSL | |
| SCHEMBL4714186 | 0.83 | PPARG (0.58) | PPARGPPARAITGA4ITGB7CTSS | |
| SCHEMBL500111 | 0.83 | PPARG (0.58) | PPARGPPARAITGA4ITGB7CTSS | |
| SCHEMBL500110 | 0.83 | PPARG (0.58) | PPARGPPARAITGA4ITGB7CTSS | |
| SCHEMBL199415 | 0.82 | PPARA (0.68) | PPARGPPARAITGA4ITGB7CTSS | |
| SCHEMBL440723 | 0.82 | PPARA (0.68) | PPARGPPARAITGA4ITGB7CTSS | |
| SCHEMBL30912525 | 0.82 | PPARG (0.59) | PPARGPPARAITGA4ITGB7CTSS | |
| SCHEMBL6674404 | 0.82 | PPARG (0.59) | PPARGPPARAITGA4ITGB7CTSS | |
| SCHEMBL3784750 | 0.82 | PPARG (0.59) | PPARGPPARAITGA4ITGB7CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081132-B1 | HYDROXAMIC ACID DERIVATIVES AND MEDICINAL UTILIZATION THEREOF | MITSUBISHI PHARMA CORP (JP) | 2004-03-10 | — | — | EP | disclosed |
| US-6610729-B1 | Inhibotors of TNF, antiinflammatory | MITSUBISHI PHARMA CORPORATION (JP) | 2003-08-26 | — | — | US | disclosed |
| EP-1081132-A1 | HYDROXAMIC ACID DERIVATIVES AND MEDICINAL UTILIZATION THEREOF | Welfide Corporation (JP) | 2001-03-07 | — | — | EP | disclosed |