Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6106298 | 0.79 | MAPK1 (0.40) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL6590358 | 0.77 | ALDH1A1 (0.37) | CYP1A2CYP2C19ALDH1A1LMNAHTT | |
| SCHEMBL6590360 | 0.77 | ALDH1A1 (0.37) | CYP1A2CYP2C19ALDH1A1LMNAHTT | |
| SCHEMBL4026878 | 0.72 | NOTUM (0.42) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL6105472 | 0.72 | GLA (0.45) | CYP1A2CYP3A4CYP2C19ALDH1A1LMNA | |
| SCHEMBL6106911 | 0.71 | MAPK1 (0.38) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL1713531 | 0.71 | SMN1; SMN2 (0.55) | CYP1A2CYP3A4CYP2C19ALDH1A1LMNA | |
| SCHEMBL1447750 | 0.70 | KMT2A (0.33) | CYP1A2ALDH1A1MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL1713808 | 0.68 | POLB (0.31) | CYP1A2ALDH1A1LMNAMAPK1THRB | |
| SCHEMBL279078 | 0.65 | KCNH2 (0.35) | MAPK1HTTSMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |