SCHEMBL6598371

SCHEMBL6598371

CCC(O)(CC)C(C)(C)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.45
TSHR P16473 2/20 0.45
HMGCR P04035 1/20 0.38
CHRM1 P11229 1/20 0.38
TBXA2R P21731 1/20 0.38
ADRA1A P35348 1/20 0.38
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
TET2 Q6N021 1/20 0.34
FFAR3 O14843 1/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
THRB P10828 1/20 0.33
KMT2A Q03164 1/20 0.33
ARG1 P05089 1/20 0.32
ARG2 P78540 1/20 0.32
ACLY P53396 1/20 0.32
FFAR1 O14842 1/20 0.32
CPT2 P23786 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7679376 0.84 TSHR (0.36) ALDH1A1TSHRMEN1KMT2AFFAR1
SCHEMBL8934753 0.82 CYP4F2 (0.39) ALDH1A1TSHRMEN1CYP1A2THRB
SCHEMBL11399339 0.78 TSHR (0.45) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL1036165 0.78 ALDH1A1 (0.45) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL6937150 0.74 TSHR (0.40) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL580509 0.73 TSHR (0.44) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL10954981 0.72 ALDH1A1 (0.38) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL10830599 0.72 TSHR (0.38) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL28448094 0.72 ALDH1A1 (0.38) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL5277664 0.72 TSHR (0.38) ALDH1A1TSHRHMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1080082-B1 INTERMEDIATES FOR THE SYNTHESIS OF EPOTHILONES AND METHODS FOR THEIR PREPARATION NOVARTIS AG (CH) 2004-10-06 EP claimed