Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 15/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308115 | 0.87 | MAPT (0.59) | F10MAPTCCR2F2THRB | |
| SCHEMBL6303111 | 0.85 | MAPT (0.63) | F10MAPTCCR2F2 | |
| SCHEMBL6307047 | 0.85 | HPGD (0.48) | F10MAPTCCR2TP53THRB | |
| SCHEMBL6596946 | 0.84 | MAPT (0.59) | F10MAPTF2THRBSMN1; SMN2 | |
| SCHEMBL6302533 | 0.84 | CCR2 (0.63) | F10MAPTCCR2 | |
| SCHEMBL6596771 | 0.83 | CCR2 (0.47) | F10MAPTCCR2TP53THRB | |
| SCHEMBL7082977 | 0.75 | ABCB11 (0.52) | F10MAPTCCR2TP53THRB | |
| SCHEMBL6785298 | 0.73 | ABCB11 (0.76) | MAPTCCR2TP53 | |
| SCHEMBL6308930 | 0.72 | MAPT (0.55) | MAPTCCR2TP53THRBSMN1; SMN2 | |
| SCHEMBL6775247 | 0.71 | CCR2 (0.65) | F10MAPTCCR2TP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150954-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| US-6569888-B1 | Such as ethyl-N-(dichlorobenzyl)-4-(3-hydroxypropylthio) indole-2-carboxylate; for treatment of arthritis | ASTRAZENECA AB (SE) | 2003-05-27 | — | — | US | disclosed |
| EP-1150954-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046198-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |