Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599324 | 0.85 | ESR1 (0.41) | MEN1KMT2ACYP2A6CYP2B6CYP2E1 | |
| SCHEMBL477489 | 0.84 | CYP2A6 (0.47) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL8051996 | 0.79 | MEN1 (0.36) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL28104229 | 0.79 | MEN1 (0.36) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL28141334 | 0.79 | USP2 (0.39) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL2091183 | 0.76 | MEN1 (0.34) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL14686301 | 0.74 | CNR1 (0.37) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL9111503 | 0.72 | MEN1 (0.32) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL27329701 | 0.72 | MEN1 (0.38) | MEN1USP2MAPTALOX15KMT2A | |
| SCHEMBL277051 | 0.71 | PELI1 (0.50) | HSD17B10CYP2A6CYP2B6CYP2E1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |