Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598549 | 0.85 | MEN1 (0.39) | ESR1ESR2CYP2A6CYP2E1CYP2B6 | |
| SCHEMBL8058493 | 0.81 | CYP2A6 (0.35) | ESR1ESR2CYP2A6CYP2E1CYP2B6 | |
| SCHEMBL477489 | 0.78 | CYP2A6 (0.47) | CYP2A6CYP2E1CYP2B6PTPRCMEN1 | |
| SCHEMBL2092294 | 0.75 | ESR1 (0.31) | ESR1ESR2CYP2A6CYP2E1CYP2B6 | |
| SCHEMBL276242 | 0.73 | ESR1 (0.50) | ESR1ESR2CYP2A6CYP2E1CYP2B6 | |
| SCHEMBL5580228 | 0.73 | KMT2A (0.41) | CHEK2MEN1KMT2A | |
| SCHEMBL5543516 | 0.72 | ERN1 (0.34) | ESR1ESR2ERN1PTPRC | |
| SCHEMBL5324715 | 0.70 | SLC1A3 (0.40) | CHEK2 | |
| SCHEMBL2096734 | 0.70 | CYP2A6 (0.33) | CYP2A6FYN | |
| SCHEMBL5105991 | 0.70 | CYP2A6 (0.52) | ESR1ESR2CYP2A6CYP2E1CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |