Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 8/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 2/20 | 0.37 |
| ▸ | UGCG | Q16739 | 2/20 | 0.37 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14243652 | 0.88 | NAAA (0.52) | NAAAPLA2G1BPLA2G2AEPHX2FAAH | |
| SCHEMBL6599302 | 0.88 | NAAA (0.52) | NAAAPLA2G1BPLA2G2AEPHX2FAAH | |
| SCHEMBL14243651 | 0.88 | NAAA (0.52) | NAAAPLA2G1BPLA2G2AEPHX2FAAH | |
| SCHEMBL8828113 | 0.87 | NAAA (0.54) | NAAAPLA2G1BPLA2G2AEPHX2FAAH | |
| SCHEMBL17756150 | 0.85 | NAAA (0.50) | NAAAPLA2G1BPLA2G2AEPHX2FAAH | |
| SCHEMBL14243737 | 0.85 | NAAA (0.50) | NAAAPLA2G1BPLA2G2AEPHX2FAAH | |
| SCHEMBL2617344 | 0.85 | NAAA (0.50) | NAAAPLA2G1BPLA2G2AEPHX2FAAH | |
| SCHEMBL13986861 | 0.83 | NAAA (0.54) | NAAAPLA2G1BPLA2G2AFAAHPPARA | |
| SCHEMBL9556953 | 0.82 | NAAA (0.57) | NAAAFAAHALDH1A1 | |
| SCHEMBL7281001 | 0.82 | NAAA (0.57) | NAAAFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080082-B1 | INTERMEDIATES FOR THE SYNTHESIS OF EPOTHILONES AND METHODS FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6350878-B1 | BASIFICATION AND IODINATION OF ALDEHYDE | NOVARTIS AG (CH) | 2002-02-26 | — | — | US | disclosed |
| EP-1080082-A1 | INTERMEDIATES FOR THE SYNTHESIS OF EPOTHILONES AND METHODS FOR THEIR PREPARATION | Novartis AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059985-A1 | INTERMEDIATES FOR THE SYNTHESIS OF EPOTHILONES AND METHODS FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1999-11-25 | — | — | WO | disclosed |