Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10515832 | 1.00 | TDP1 (0.63) | TDP1MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL29405545 | 1.00 | TDP1 (0.63) | TDP1MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL11454521 | 0.87 | TDP1 (0.60) | TDP1MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL28908860 | 0.83 | TDP1 (0.47) | TDP1MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL28908861 | 0.83 | TDP1 (0.47) | TDP1MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL12402952 | 0.80 | GABRA1 (0.45) | TDP1MAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL31074940 | 0.80 | CDK4 (0.55) | TDP1MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL21676102 | 0.80 | TDP1 (0.44) | TDP1MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL20292376 | 0.80 | CDK4 (0.55) | TDP1MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL16599459 | 0.80 | TDP1 (0.44) | TDP1MAPTALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279095-A1 | Chemotherapeutic composition | SHIKOKU CHEMICALS CORPORATION (JP) | 1988-08-24 | — | — | EP | claimed |
| EP-0209843-A2 | Benzylpiperazine compound, preparation thereof, pharmaceutical composition, and use | KANEBO, LTD. (JP) | 1987-01-28 | — | — | EP | claimed |
| CN-114105844-A | Novel laccase inhibitor thiosemicarbazone compound and preparation method and application thereof | 中国农业大学 | 2022-03-01 | — | — | CN | disclosed |
| EP-2739626-B1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INT BV (NL) | 2016-05-04 | — | — | EP | disclosed |
| US-9096599-B2 | Spiroindoline compounds | INTERVET INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140163056-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INC. | 2014-06-12 | — | — | US | disclosed |
| EP-2739626-A1 | NOVEL SPIROINDOLINE COMPOUNDS | Intervet International B.V. (NL) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013017678-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INTERNATIONAL B.V. (NL) | 2013-02-07 | — | — | WO | disclosed |
| EP-1458679-A2 | PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053923-A2 | PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-07-03 | — | — | WO | disclosed |
| EP-0330132-A1 | Azolylmethylcycloalkyloxiranes, their preparation and use as plant-protective agents | BASF Aktiengesellschaft (DE) | 1989-08-30 | — | — | EP | disclosed |
| US-4710513-A | Substituted pyranone inhibitors of cholesterol synthesis | MERCK & CO., INC. (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0209843-A2 | Benzylpiperazine compound, preparation thereof, pharmaceutical composition, and use | KANEBO, LTD. (JP) | 1987-01-28 | — | — | EP | disclosed |
| US-4567289-A | ANTICHOLESTEROL ANTILIPEMIC | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4459422-A | Substituted pyranone inhibitors of cholesterol synthesis | MERCK & CO., INC. (US) | 1984-07-10 | — | — | US | disclosed |
| US-4448710-A | Corrosion inhibitors including a 3-dialkylamino-3-phenylethenylprop-1-yne | GAF CORPORATION (US) | 1984-05-15 | — | — | US | disclosed |
| EP-0080794-A1 | Corrosion inhibitors containing N,N,1-trisubstituted prop-2-ynyl amines | GAF CORPORATION (US) | 1983-06-08 | — | — | EP | disclosed |
| US-4375475-A | ANTICHOLESTEROL AGENTS | MERCK & CO., INC. (US) | 1983-03-01 | — | — | US | disclosed |
| EP-0024348-A1 | Substituted 6-Phenethyl-and phenylethenyl-3,4,5,6-tetrahydro-4-hydroxytetraydropyran-2-ones in the4-R trans stereoisomeric forms and the corresponding dihydroxy acids, process for preparing and pharmaceutical composition comprising them | MERCK & CO. INC. (US) | 1981-03-04 | — | — | EP | disclosed |
| US-4087549-A | Sulphonic acid containing indenyl derivatives | MERCK & CO., INC. (US) | 1978-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163056-A1 | NOVEL SPIROINDOLINE COMPOUNDS | PKD2, PKD1, REN | TDP1 4688/4885MAPT 3915/4885ALDH1A1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.