Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 2/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | NAT1 | P18440 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599383 | 0.85 | IMPDH2 (0.37) | ESR1CHEK1PDCD1CD274IMPDH2 | |
| SCHEMBL8040627 | 0.81 | ESR1 (0.35) | ESR1IMPDH2PTGER2CSNK2A1LPL | |
| SCHEMBL27665928 | 0.80 | ESR1 (0.36) | ESR1PTGER2ERN1LPLLIPG | |
| SCHEMBL2097211 | 0.79 | ESR1 (0.35) | ESR1PTGER2 | |
| SCHEMBL477331 | 0.78 | IMPDH2 (0.46) | PDCD1CD274IMPDH2CSNK2A1NAT1 | |
| SCHEMBL2095531 | 0.76 | GABRA1 (0.34) | ESR1LPLLIPG | |
| SCHEMBL2090149 | 0.75 | ESR1 (0.31) | ESR1 | |
| SCHEMBL2096300 | 0.70 | MEN1 (0.34) | — | |
| SCHEMBL4652625 | 0.70 | PDCD1 (0.52) | ESR1PDCD1CD274 | |
| SCHEMBL2010826 | 0.68 | ESR1 (0.39) | ESR1CHEK1IMPDH2PTGER2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |