Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312276 | 0.82 | HTR2C (0.47) | HTR2CKDM4EMAPKAPK2OPRM1OPRL1 | |
| SCHEMBL6599323 | 0.79 | SLC22A12 (0.40) | HTR2CKDM4EMAPKAPK2OPRM1OPRL1 | |
| SCHEMBL1680249 | 0.75 | NPC1 (0.45) | ALDH1A1MEN1MAPK1KMT2ACYP3A4 | |
| SCHEMBL6319301 | 0.75 | HTR2C (0.43) | HTR2CKDM4EMAPKAPK2TRPV1MEN1 | |
| SCHEMBL6261873 | 0.74 | HTR2C (0.42) | HTR2CKDM4EMAPKAPK2OPRM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6313986 | 0.74 | HTR2C (0.43) | HTR2CKDM4EMAPKAPK2TRPV1MEN1 | |
| Hydrochloric Acid SCHEMBL6313991 | 0.73 | HTR2C (0.42) | HTR2CKDM4EMAPKAPK2OPRM1ALDH1A1 | |
| SCHEMBL6313000 | 0.73 | L3MBTL1 (0.44) | HTR2CKDM4ETRPV1ALDH1A1MAPK1 | |
| SCHEMBL6312111 | 0.71 | KDM4E (0.49) | HTR2CKDM4EMAPKAPK2OPRM1OPRL1 | |
| SCHEMBL19187423 | 0.69 | MAPT (0.47) | HTR2CDRD2DRD3KDM4EMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056729-B1 | N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL]GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA | PFIZER PROD INC (US) | 2004-12-29 | — | — | EP | claimed |